Biomedical question answering requires not only accurate extraction of information from scientific literature but also reliable integration of evidence across multiple documents. This study presents a question-type-specific large language model (LLM) framework for BioASQ 14b Task B, designed to improve answer robustness and evidence grounding in biomedical question answering. Rather than applying a single prompting strategy to all questions, the framework selects different inference procedures for yes/no, factoid, and list questions according to their distinct reasoning and evaluation requirements. For yes/no questions, snippet shuffling and self-reflection are used to reduce sensitivity to evidence ordering and improve decision stability. For factoid questions, full-snippet input is combined with chain-of-thought-based in-context learning to support accurate biomedical entity identification. For list questions, a multi-agent architecture is employed, in which evidence extraction, candidate generation, answer verification, and final aggregation are handled collaboratively. Preliminary experiments on BioASQ 13b were used to identify effective inference strategies for each question type, and the resulting framework was subsequently evaluated in the official BioASQ 14b Task B challenge. In the official evaluation, our framework showed competitive performance across multiple batches and achieved first place in the factoid subtask of Batch 4. These results demonstrate the effectiveness of combining question-type-specific inference, ensemble prediction, and agent-based verification for reliable biomedical question answering.
Recent LLM-based mathematical reasoning agents have begun to tackle research-level problems and, in several cases, have contributed to the resolution of open problems. However, scaling and orchestrating such agents effectively remains challenging, due to the difficulty of coordinating parallel proof search while keeping intermediate claims organized and reliable. In this paper, we propose Danus, an orchestration system for research-level mathematical reasoning centered on a shared fact graph as a global memory-management mechanism. Danus consists of a main agent that performs planning and coordination, multiple worker agents that carry out proof search in parallel, and a stateless verifier that checks proposed mathematical claims before they are admitted into the fact graph. Each verified fact is stored together with its proof and logical dependencies, allowing the system to build long arguments incrementally while keeping the shared proof state organized. The main agent periodically summarizes the evolving proof state, redirects workers across promising directions, and supports interaction with human mathematicians through progress reports. We evaluate Danus through six research-level case studies in algebraic geometry, singularity theory, and combinatorics, illustrating how the fact-graph memory mechanism enables Danus to construct long, detailed mathematical proofs. Our results suggest that fact-graph-based orchestration provides an effective route toward scaling mathematical reasoning agents for long-horizon research problems. Danus is open source at https://github.com/frenzymath/Danus.
Vision-Language Models (VLMs) are increasingly utilized as the conditioning backbone for diffusion-based image editing due to their remarkable multimodal reasoning capabilities. While standalone VLMs demonstrate strong localization capabilities, editing pipelines frequently struggle to maintain this accuracy, particularly in complex, multi-entity scenes. In this work, we investigate this performance gap, hypothesizing that it stems from treating the VLM as a condition encoder. In this role, the model is restricted to a single forward pass, preventing the autoregressive generation process for which it was optimized, thereby failing to fully expose its capabilities. To investigate whether this spatial understanding persists when the VLM is used as a condition encoder, we introduce Analysis-by-Proxy. In this framework, we train a lightweight, interpretable proxy model on the VLM's intermediate representations using an auxiliary localization task. By analyzing the VLM through this proxy, we uncover the specific VLM representations that encode localization information. Our findings expose a fundamental mismatch between how spatial knowledge is represented within a VLM condition encoder and how it is extracted by current editing pipelines. We reveal that under single-pass constraints, the localization signal does not reliably propagate to the predefined layer configurations commonly used for conditioning. Instead, this crucial signal remains hidden within intermediate representations, at locations that vary depending on the input prompt. Using our introduced Analysis-by-Proxy framework, we reveal the fundamental failures of existing condition extraction strategies in editing pipelines, opening the door to more principled design of conditioning architectures.
Latent reasoning methods perform multi-step inference entirely in the model's continuous hidden states, promising more compact and efficient reasoning. However, these opaque hidden states raise a question of faithfulness: whether these latent reasoning steps causally drive the final answer. Prior work investigates this question at converged checkpoints and reports several unfaithful behaviors, such as latent reasoning steps that can be replaced without changing the answer, but leaves how these behaviors form during training unexamined. We instead track how faithfulness evolves across saved checkpoints for different latent reasoning paradigms, applying a verifiable counterfactual edit on the input and a noise-ablation activation patch on the latent reasoning steps. We find that (i) at the output level, latent reasoning methods can look similarly unfaithful at convergence under counterfactual edits while following qualitatively divergent trajectories; (ii) at the activation level, the causal contribution of latent reasoning steps to the final answer decays across training for both paradigms, with the examples that flip on the output side in (i) also being the examples on which this contribution decays; and (iii) the activation-level trajectory diverges by answer format, decaying on binary choice and rising on open-ended decoding. These findings highlight that latent reasoning faithfulness depends on training stage and answer format.
Recent text-to-image models such as DALLE-3 excel at following diverse prompts yet remain blind to individual aesthetic preferences. We study personalized image generation, where models must align outputs with a user's implicit visual preferences based on a few historically preferred images and a short prompt. To this end, we introduce PIPBench, the first profile-inclusive benchmark for evaluating personalized image generation. We further propose a novel data construction pipeline that leverages psychological and demographic profiling dimensions for both real-user data collection and scalable agent-based data generation. Using PIPBench, we conduct a thorough evaluation of representative line of methods. Our experiments reveal key limitations in existing methods, suggesting new challenges and opportunities for personalized text-to-image synthesis. Project page: https://wuyuhang05.github.io/PIPBench/
Retargeting human object interaction demonstrations to physics based simulation requires reproducing not only body motion but also the object motion and contacts that make manipulation succeed. However, position only hand trajectories do not specify the contact forces needed to manipulate objects, and directly tracking them can overconstrain contact rich finger behavior. We introduce WristMimic, a wrist guided whole body control framework that explicitly separates contact free body motion from contact rich hand manipulation. The contact free body and wrist are guided by kinematic pose targets, whereas the fingers are not directly supervised by human hand pose. Instead, they learn grasping and manipulation behaviors from object tracking and contact outcomes. Our key insight is that the wrist is the natural gate between these two regimes. It is largely free from contact and can be tracked kinematically, yet it determines the global hand configuration and places the fingers within reachable grasp affordances. To ensure reliable wrist placement during interaction, we introduce wrist specific reset constraints and reward prioritization. Experiments show that WristMimic matches or surpasses methods using full finger pose supervision while enabling finger agnostic retargeting across diverse hand embodiments.
Data from Singapore indicated that about 31% of the population had evidence of Helicobacter pylori infection. Persistent H. pylori infection is associated with chronic active gastritis and peptic ulcer disease, and its eradication is key to gastric cancer prevention. However, evidence supporting \textit{H. pylori} positivity and H. pylori-associated gastritis may be distributed across heterogeneous coded and free-text report fields and may require contextual interpretation of assertion and negation, limiting keyword search, and making manual review difficult to scale. We conducted a retrospective pilot evaluation of the Nimblemind Multi-Agent System (nMAS), a field-name-driven, evidence-linked extraction workflow, using 54 de-identified gastric biopsy pathology reports from a large healthcare system in Singapore. Four clinician-scoped binary fields were evaluated: gastric/stomach biopsy, biopsy status, H. pylori positivity, and H. pylori-associated gastritis. Across 216 feature-case decisions, nMAS correctly classified 213, corresponding to 98.61% overall accuracy. A separately implemented UMA-style MiniMax M2.5 comparator produced similar aggregate and per-field classification metrics. Although predictive performance was similar, nMAS maintained unified report-level outputs with supporting source sentences; the demonstrated contribution is therefore workflow integration and traceability rather than predictive superiority. Under an illustrative, unmeasured scenario, reviewing 1,000 reports at five minutes per manual review versus five seconds per evidence-linked verification would reduce review time from 83.3 to 1.4 staff-hours, corresponding to 81.9 staff-hours and about USD~6,100 in potential staff-time value. Larger multi-institutional studies should evaluate evidence-span correctness, clinician verification time, and generalizability.
Concept unlearning in text-to-image diffusion models is critical for safe and practical deployment: with rising privacy concerns, copyright disputes, trademark constraints, and safety regulations, deployed systems must be able to suppress unwanted concepts after training. Existing methods often remove the target concept effectively, but practical unlearning also requires an equally fundamental property: the unlearned model should retain quality, diversity, and semantic coverage on benign generation. The gold standard is a retain-only model trained from scratch without the unwanted data. However, common erasure objectives do not specify which post-unlearning distribution should approximate this reference, leaving retention as an implicit consequence of the update rule. We propose TILDE, TILt-based Distributional Erasure, which formulates concept unlearning as a distributional alignment problem: the desired target is the minimum-deviation conditional distribution from the pretrained model under a forgetting constraint. This energy-tilted, anchor-free target suppresses concept-expressing images while preserving benign relative mass for each prompt. We instantiate this principle with residual $\nabla$-GFlowNet training, which learns the score correction induced by the forget energy relative to the pretrained diffusion model. Across objects, artistic styles, and characters, TILDE achieves strong forgetting while improving retention and distributional fidelity over prior baselines.
This paper introduces Diffusion Semi-Relaxed Fused Gromov-Wasserstein (DsrFGW), a novel method for graph comparison that unifies node features and structural connectivity through optimal transport. While traditional Gromov-Wasserstein and semi-relaxed variants (srGW, srFGW) capture graph structure, they often struggle with sparse, noisy, or partially observed graphs. Inspired by Graph Diffusion Distance, which posits graphs are similar if they enable similar information transmission patterns, DsrFGW incorporates diffusion processes allowing information propagation across nodes, capturing local and global structural patterns while reducing sensitivity to noise or missing edges. An extensive evaluation on 36 synthetic pairwise graph matching tasks (easy, medium, hard) demonstrates consistent superiority over srFGW, achieving accuracy improvements of 0-20 percentage points and dramatic Adjusted Rand Index (ARI) gains: in medium-difficulty scenarios, srFGW often achieves negative ARI (worse than random) while DsrFGW offers better performance in terms of both internal and external clustering quality measures (i.e., Adjusted Rank Index and Accuracy with respect to the true underlying clusters, respectively). Even under severe noise, DsrFGW improves clustering quality in 92% of the synthetic tasks with optimal diffusion scales adapting to problem difficulty, establishing DsrFGW as a robust framework for graph comparison under structural uncertainty.
X-ray fluorescence (XRF) spectroscopy is a key modality for material analysis in cultural heritage. However, automated learning from XRF spectra remains challenging: XRF spectra are complex one-dimensional signals composed of sharp elemental peaks, broader structures, and background variations that are not taken into account by existing learning-based models. This paper introduces XRFormer, a transformer architecture tailored to XRF spectra through a multiscale convolutional tokenizer that injects locality and multi-resolution inductive biases before global self-attention. The tokenizer progressively reduces spectral resolution while increasing embedding dimensionality, and the resulting token sequence is processed by a standard transformer encoder. We further investigate self-supervised pretraining for XRF representation learning using Masked Spectral modeling (MSM) and a physics-informed Peak Presence Prediction (PPP) objective. Experiments on the Pigments Checker STANDARD v.5 dataset for pigment identification and unmixing show that XRFormer consistently outperforms ViT, SpectralFormer (with and without CAF), and a 1D-CNN baseline for pigment identification. For pigment unmixing, XRFormer achieves robust abundance estimation while maintaining significantly higher parameter efficiency than SpectralFormer, operating at a lower token resolution (128 vs. 512 tokens) and with less than half the number of parameters (1.5M vs. 3.37M). MSM yields consistent gains across both tasks, while PPP further enhances performance for both identification and unmixing when tuned with an appropriate peak prominence. These results highlight multiscale, modality-aware tokenization as an effective and parameter efficient foundation for transformer-based XRF modeling under data-limited conditions. A GitHub repository is provided at https://github.com/sofiane1010/XRFormer.
Visual counting is a fundamental pillar of multimodal intelligence, requiring a seamless integration of fine-grained grounding and spatial reasoning. While Multimodal Large Language Models (MLLMs) have achieved remarkable success in qualitative scene understanding, their quantitative precision remains a significant bottleneck, often characterized by persistent numerical hallucinations. Existing counting benchmarks primarily focus on basic perception in simplified contexts, failing to capture the complex failure modes that emerge under logical constraints or adversarial conditions. To address these limitations, we introduce HoloCount, a holistic and diagnostically rich benchmark structured around a three-level hierarchical taxonomy. HoloCount evaluates MLLMs across: (1) Semantic Counting, focusing on atomic and property-based enumeration; (2) Analytical Counting, assessing logical composition through spatial and set-based reasoning; and (3) Robustness Testing, probing model integrity against adverse scenarios and grounded counter-priors, such as high-density scenes and linguistic biases. Through an exhaustive evaluation of over 20 state-of-the-art MLLMs, we reveal a critical performance gap: even top-tier models degrade significantly as tasks transition from perception to complex analytical reasoning and adverse scenarios. Our findings provide a systematic landscape of current MLLM counting capabilities and offer a roadmap for developing more grounded and reliable multimodal systems. The dataset is available at https://mm-mvr.github.io/HoloCount/.
Large language model coding agents increasingly perform open-ended data modeling and analysis. These agents are stochastic and adaptive, and therefore their autonomous model discovery behavior cannot be adequately characterized by a single benchmark run. In this work, we propose an experimental design and analysis framework for systematically evaluating this discovery process, quantifying its variability, and identifying important factors. The proposed framework treats these agents as stochastic model-discovery operators, which map task-specific discovery data and an optimization target to a fitted model. Specifically, we investigate two such operators, Codex and Claude Code, under controlled experimental factors including agent's reasoning effort, task, optimization metric, and composition of training data. For each agent-task-metric combination, regression models and inference are conducted for multiple responses such as output quality, dollar cost, wall-clock time, and process complexity. Furthermore, we develop a utility-aligned canonical decomposition to characterize the dominant direction of the reasoning-effort effect and to assess whether that direction aligns with a performance-cost utility direction. The proposed framework is demonstrated on a testbed of networked word-forming games with insightful findings on reasoning effort with respect to cost and process complexity.